蔡进辉个人简介
基本信息
姓名：蔡进辉
出生年月：1992.10
学位：博士
职称：校聘教授
研究领域（方向）：（1）有机硒化学； （2）有机光催化合成转化反应； （3）廉价金属催化的[2+2+n]环加成反应 （4）有机电合成
联系方式：
邮箱：jinhuicai@usc.edu.cn;15898595191@163.com
课题组主页：https://www.x-mol.com/groups/Cai-Jinhui
个人简介
蔡进辉，男，1992年生，湖南益阳人，博士，校聘教授，硕士生导师。现主持国家自然科学基金青年项目、湖南省自然科学青年项目、南华大学博士科研启动基金等，参与多项面上项目；目前在Chem、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、ACS Catalysis、Chem Catalysis、Org. Lett.、Green Chem.、Green Synth. Catal.、Org. Chem. Front.、Adv. Synth. Catal.、J. Org. Chem.等期刊上发表论文42篇，其中以通讯作者、第一作者（含共一）、导师第一本人第二发表论文36篇；授权专利2项。
教育经历
2017/09-2020/06 武汉大学，化学与分子科学学院，博士，导师：刘文博
2014/09-2017/06 湘潭大学，化学学院，硕士，导师：邓国军、黄华文
2013/09-2014/05 中科院化学所，分子识别与功能实验室，联培本科生，导师：王从洋
2010/09-2014/06 湘潭大学，化学学院，学士
科研、学术与访学工作经历
1. 2021/06-现今，南华大学，化学化工学院，校聘教授
2. 2020/07-2021/06，浙江大学，化学系，博士后，合作导师：史炳锋
主持或参加科研项目（课题）情况
2024.01—2026.12 基于光诱导钴催化不对称[2+2+2]环加成反应合成新型手性氮杂螺烯化合物及其性能研究，国家自然科学基金（22301128），主持，经费30万；
2022.01—2024.12 基于钴催化1,6-烯炔化合物和腈类化合物的不对称环化反应的研究，湖南省自然科学基金（2022JJ40353），主持，经费5万元；
2021.06—至今 廉价金属钴催化1,6-烯炔化合物的不对称碳环化反应的研究，南华大学博士启动经费，主持，经费30万元。
主要论文：
1.Chuanquan Chu, Dahan Wang,* Sheng Tao, Junyuan Tang, Jinbing Liu, Weishuang Li,* Huaixin Wei,* Mingming Yu, and Jinhui Cai,* Divergent Synthesis of 2-Quinolinyl-Substituted Thiophenes Via Acid-Promoted Three-Component Cyclization. Adv. Synth. Catal. 2025, 10.1002/adsc.70048.
2.Chuanquan Chu, Jinhui Peng, Lijuan Jin, Yilin Chen, Dahan Wang,* Jinbing Liu, Junyuan Tang, Zi Yang,* Mingming Yu, and Jinhui Cai*, Synthesis of 4-(arylthio)isoquinolin-1(2H)-ones via TBHP-mediated sequential amidation/thioetherification of N-alkylisoquinolinium salts. Org. Biomol. Chem. 2025, 10.1039/D5OB01074H.
3.Zhouting Zeng, Yanfeng Ma*, Zi Yang*, Mingming Yu, and Jinhui Cai*, Bromide-Catalyzed Radical Cyclization of Biarylboronic Acids and Se/Te Powder. J. Org. Chem. 2025, 10.1021/acs.joc.5c01441.
4.Zhouting Zeng, Peng Huang, Weishuang Li*, Huaixin Wei*, Wenke Wang, Huimei Zhong, Mingming Yu, and Jinhui Cai*, Electrochemical Synthesis of 2-Selenylnaphthalenes with Alkynyl Alkyl Alcohols and Diselenides. J. Org. Chem. 2025, 90, 11197-11206.
5.Zhouting Zeng, Huaixin Wei*, Wei-Min He*, Mingming Yu, Zu-Li Wang, and Jinhui Cai*, Synthesis of Selenylated Maleimides and Alkenes via Bromide Catalysis. Chin. J. Org. Chem. 2025, 10.6023/cjoc202506004.
6.Zhouting Zeng+, Feng Zhao+, Huaixin Wei*, Mingming Yu, and Jinhui Cai*, Synthesis of 5-Arylselenyluracils via Bromide-Catalyzed Selective C(sp2)-H Selenylation of Uracils. Asian J. Org. Chem. 2025, 14, e00415. (+共一)
7.Chuanquan Chu, Yu Liu, Min Mao, Dahan Wang,* Jinbing Liu, Huaixin Wei*, Mingming Yu, and Jinhui Cai*, Synthesis of 1,3,4-thiadiazoles from elemental sulfur via three-component cyclization under metal-free conditions. Org. Biomol. Chem. 2025, 23, 5101-5105.
8.Jinhui Cai*, Zhouting Zeng, Qiao-Lin Wang*, and Weishuang Li*, Recent Advances in the Assembly of Organoselenyl-Substituted (Thio)Chromones and 4-Quinolones. Adv. Synth. Catal. 2025, 367, e02500210.
9.Jinhui Cai*, Zhouting Zeng, Peng Huang, Qianwen Gao, and Guiyang Zhang, Electrocatalytic Selenylation of 2-Alkenylanilines for the Synthesis of 3-Selanylindoles. Eur. J. Org. Chem. 2025, 28, e202500202.
10.Li-Gang Bai+, Yu-Qing Zheng+, Han-Nan Chen+, Jinhui Cai, and Wen-Bo Liu*, Access to Enantiopure Spiropyridines Enabled by Enantio-Relay Double [2 + 2 + 2] Cycloaddition and Kinetic Resolution [2 + 2 + 2] Cycloaddition of Alkynes and Nitriles. J. Am. Chem. Soc. 2025, 147, 14574-14584.(+共一)
11.Jinhui Cai,* Kaili Cen, Jiahao Wei, Hongyi Lin and Haixia Zhang, Assembly of Fluoranthenes via Cobalt-Catalyzed [2 + 2 + 2] Cycloaddition of 1,6-Diynes with Alkynes. J. Org. Chem. 2025, 90, 3001-3010.
12.Jinhui Cai,* and Zhouting Zeng, First Bromide-Catalyzed Selenylation of 2-Alkyn-1-One O-Methyloximes Enabled the Synthesis of 4-Selenylated Isoxazoles. Adv. Synth. Catal. 2025, 367, e202401477.
13.Jinhui Cai,* Wenting Zhang, Muhammad Usman,* Weishuang Li,* and Yanjun Xie*, Recent advances in asymmetric synthesis of chiral benzoheterocycles via Earth-abundant metal catalysis. Org. Chem. Front. 2024, 11, 6534-6557.
14.Jinhui Cai,* Kaili Cen, Weishuang Li,* Hongyi Lin, Haixia Zhang, Electrochemical Synthesis of 4-Selenylated Oxazolones via Oxyselenylation of Ynamides. Adv. Synth. Catal. 2024, 367, e202401146.
15.Wangzhen Shen, Kaili Cen, Zhouting Zeng, Jinhui Cai*, Synthesis of Diaryl Diselenides and Ditellurides via Bromide-Catalyzed C–Se/C–Te Bond Formation Using Se/Te Powder and Boronic Acid. Synlett 2025, 36, 835-840.
16.Jinhui Cai,* Kaili Cen, Hongyi Lin, Haixia Zhang, Nannan Zhou, and Qiaolin Wang*, Selenylation of N-(P-Methoxyaryl)Propiolamides via CuBr2 Catalysis: Synthesis of 3-Selenospiro[4,5]Decatrienones via Ipso-Cyclization. ChemCatChem 2024, 16, e202400929.
17.Jinhui Cai,* Kaili Cen, Ziyi Zhai, Jiahao Wei, Yuan Liu, Yuting Feng, Junhong Yu, Huiling Liu, Feng Zhao* and Qiaolin Wang*, Synthesis of Polyaryl-Substituted Azafluoranthenes via Co-Catalyzed [2+2+2] Cycloaddition of 1,6-Diynes with Nitriles. Adv. Synth. Catal. 2024, 366, 3913-3919.
18.Kaili Cen+, Mixia Ouyang+(本科生), Guojun He, Zhouting Zeng, Qiaolin Wang, Xin Yu*, Feng Zhao*, and Jinhui Cai*, Synthesis of naphtho[1,2-b]furan-2-carbaldehydes and naphtho[2,1-b]furan-2-carbaldehydes via electrocatalytic 3,3-rearrangement/cyclization of propargylic aryl ethers under mild conditions. Green Synth. Catal. 2024, 10.1016/j.gresc.2024.05.008. (+共一)
19.Kaili Cen+, Yuan Liu+(本科生), Junhong Yu+(本科生), Zhouting Zeng, Qian Hou, Guojun He, Mixia Ouyang, Qiaolin Wang, Dahan Wang*, Feng Zhao*, and Jinhui Cai*, Electrocatalytic Cascade Selenylation/Cyclization/Deamination of 2-Hydroxyaryl Enaminones: Synthesis of 3-Selenylated Chromones under Mild Conditions. J. Org. Chem. 2024, 89, 8632-8640. (+共一)
20.Kaili Cen+, Ziyi Zhai+(本科生), Yuan Liu+(本科生), Jiahao Wei, Mixia Ouyang, Guojun He, Shuyu Huang, Feng Zhao,* and Jinhui Cai*, Concise synthesis of succinimide-fused 1,3-cyclohexadienes via Co-catalyzed [2 + 2 + 2] cycloaddition of 1,6-diynes and maleimides. Org. Chem. Front. 2024, 11, 3257-3262. (+共一)
21.Kaili Cen+, Zhouting Zeng+, Wangzhen Shen+, Yuting Feng, Pingzhi Yan, Jiahao Wei, Qian Hou, Junjie Fu, Xiaotong Xia, and Jinhui Cai*, Cu-Catalyzed C(sp2)-H Bond Aminosulfonylation of Maleimides. Adv. Synth. Catal. 2023, 365, 2530–2535. (+共一)
22.Kaili Cen+, Jiahao Wei+(本科生), Yuan Liu+(本科生), Zhixuan Tan, Xinye Wang, Dahan Wang,* Wei-Min He,* and Jinhui Cai*, Electrochemical Selenylation of Alkynyl Aryl Ketones: Efficient Synthesis of 3-Selenylated Chromones under Catalyst- and Chemical-Oxidant-Free Conditions. Eur. J. Org. Chem. 2023, 26, e202300968. (+共一)
23.Kaili Cen+, Jiahao Wei+(本科生), Yuting Feng+(本科生), Yuan Liu, Xinye Wang, Yangyu Liu, Yalin Yin, Junhong Yu, Dahan Wang* and Jinhui Cai*, Synthesis of fused 3-trifluoromethyl-1,2,4-triazoles via base-promoted [3+2] cycloaddition of nitrile imines and 1H-benzo[d]imidazole-2-thiols, Org. Biomol. Chem. 2023, 21, 7095–7099. (#共同第一作者)
24.Dahan Wang*, Xiaoyuan Wan, Yazheng Zhou, Jinbing Liu, Jinhui Cai*, Guo-Jun Deng*, Facile Synthesis of Fully Substituted 1,2,4-Triazoles via [3+2] Cycloaddition of Nitrileimines with Amidine under Transition Metal-Free Conditions. Asian J. Org. Chem. 2023, 12, e202200674.
25.Jinhui Cai*, Kaili Cen, Wangzhen Shen, Li-Gang Bai, Wen-Bo Liu,* [2+2+2] Cycloaddition of nitriles to enantioenriched and highly substituted pyridines. Chem Catal. 2022, 2, 2889.
26.Kaili Cen#, Muhammad Usman#, Wangzhen Shen, Meijing Liu, Rong Yang, Jinhui Cai* A review for the assembly of multi-substituted pyridines via Co-catalyzed [2+2+2] cycloaddition with nitriles. Org. Biomol. Chem. 2022, 20, 7391 − 7404.
27.Jinhui Cai+, Li-Gang Bai+, Yiliang Zhang, Zhen-Kai Wang, Fei Yao, Jin-Huang Peng, Wei Yan, Yan Wang, Chao Zheng, Wen-Bo Liu, Nickel-Catalyzed Enantioselective [2+2+2] Cycloaddition of Malononitriles and Alkynes. Chem 2021, 7, 799 – 811.
28.Huawen Huang*, Jinhui Cai, Xiaochen Ji, Fuhong Xiao, Ya Chen, Guo-Jun Deng*, Internal Oxidant-Triggered Aerobic Oxygenation and Cyclization of Indoles under Copper Catalysis. Angew. Chem. Int. Ed. 2016, 55, 307 − 311. (导师第一，本人第二)
29.Qiang Wei+, Jinhui Cai+, Xu-Dong Hu, Jing Zhao, Hengjiang Cong, Chao Zheng, and Wen-Bo Liu, Enantioselective Access to γ-All-Carbon Quaternary Center-Containing Cyclohexnaones by Palladium-Catalyzed Desymmetrization. ACS Catal. 2020, 10, 216 – 224. (共一)
30.Jinhui Cai+, Feifei Li+, Guo-Jun Deng, Xiaochen Ji*, Huawen Huang*, The Cyclopropylimine Rearrangement/Povarov Reaction Cascade for the Assembly of Pyrrolo[3,2-c]quinoline Derivatives. Green Chem. 2016, 18, 3503 – 3506. (共一)
31.Jinhui Cai, Zhen-Kai Wang, Yun-Hao Zhang, Fei Yao, Xu-Dong Hu, and Wen-Bo Liu, Synthesis of Polysubstituted 2-Naphthols by Palladium-Catalyzed Intramolecular Arylation/Aromatization Cascade. Adv. Synth. Catal. 2020, 362, 1303 – 1308.
32.Jinhui Cai, Zhen-Kai Wang, Muhammad Usman, Zhi-Wu Lu, Xu-Dong Hu, and Wen-Bo Liu, Enantioselective Synthesis of β Quaternary Carbon-Containing Chromanes and 3,4-Dihydropyrans via Cu-Catalyzed Intramolecular C−O Bond Formation. Org. Lett. 2019, 21, 8852 – 8856.
33.Jinhui Cai, Qiang Wei, Xu-Dong Hu, Yan Zhang, Weishuang Li, Hengjiang Cong, Wei Liu, Wen-Bo Liu, Enantioselective Construction of Bridgehead Quaternary Carbon Containing Bicyclo[3.3.1]nonanes by Palladium-Catalyzed Desymmetric Arylation. Synthesis 2018, 50, 1661 – 1666.
34.Yujia Xia+, Jinhui Cai +, Huawen Huang* and Guo-Jun Deng*, Synthesis of polysubstituted pyridines from oxime acetates using NH4I as a dual-function promoter. Org. Biomol. Chem. 2018, 16, 124 − 129. (共一)
35.Huawen Huang*, Jinhui Cai, Hao Xie, Jing Tan, Feifei Li, and Guo-Jun Deng*, Transition-Metal-Free N−O Reduction of Oximes: A Modular Synthesis of Fluorinated Pyridines. Org. Lett. 2017, 19, 3743 − 3746. (导师第一，本人第二)
36.Huawen Huang*, Jinhui Cai, Lichang Tang, Zilong Wang, Feifei Li, Gu-Jun Deng*, Metal-Free Assembly of Polysubstituted Pyridines from Oximes and Acroleins. J. Org. Chem. 2016, 81, 1499 − 1505. (导师第一，本人第二)
37.Huawen Huang*, Jinhui Cai, Guo-Jun Deng*, O-Acyl Oximes: Versatile Building Blocks for N-heterocycle Formation in Recent Transition Metal Catalysis, Org. Biomol. Chem. 2016, 14, 1519 − 1530. (导师第一，本人第二)
38.Zhi-Wu Lu#, Xu-Dong Hu#, Hui Zhang, Xiao-Wen Zhang, Jinhui Cai, Muhammad Usman, Hengjiang Cong, Wen-Bo Liu, Enantioselective Assembly of Cycloenones with a Nitrile-Containing All-Carbon Quaternary Center from Malononitriles Enabled by Ni-Catalysis. J. Am. Chem. Soc. 2020, 142, 7328 – 7333.
专利：
1.刘文博，蔡进辉，一种季碳中心的全取代吡啶化合物及其制备方法，中国专利，专利号：ZL202010507993.7。
2.黄华文，蔡进辉，谢艳军，邓国军，2,3a-二取代-3H–吡唑并[1,5-a]吲哚-4(3aH)-酮、衍生物及其合成方法，中国专利，专利号：ZL201510675567.3。
二、出版的著作（教材）及获奖
无
