王华敏个人简介
基本信息
姓名：王华敏
出生年月：1989.11
学位：博士
职称：校聘教授
研究领域（方向）：不对称催化；生物催化合成；绿色催化合成研究
联系方式：
邮箱：huaminwang@usc.edu.cn
个人简介
王华敏，男，1989年11月生，江西赣州人，博士，校聘教授，硕士生导师。现任化学化工学院科研办主任，兼职研究生秘书。现主持湖南省自然科学基金青年项目，湖南省教育厅重点项目，南华大学博士启动基金等项目，目前已在Angew. Chem. Int. Ed.、JACS、Org. Lett.、Chem. Eur. J.、iscience、Chem. Sci.、Chem. Commun.、Green Chem.、ACS Catalysis、Org. Biomol. Chem.、Chinese J Org Chem.等期刊上发表论文20余篇，以第一作者或通讯作者发表学术论文10篇。
教育经历
2015/09-2019/06，华东师范大学，化学与分子工程学院，博士，导师：张俊良
2012/09-2015/06，湘潭大学，化学院，硕士，导师：邓国军
2008/09-2012/06，江西师范大学，化学化工学院，本科/学士
科研、学术与访学工作经历
1.2021/01-现今，南华大学，化学化工学院，校聘教授
2.2019/08-2021/09，美国南佛罗里达大学，博士后研究
主持或参加科研项目（课题）情况
1. 2021–至今，基于膦PⅢ/PV=0催化的手性杂环合成研究（博士启动经费），主持；
2. 2022.01–2024.12，手性叔膦催化的不对称反应构建轴手性化合物研究（湖南省科学基金青年项目），主持；
3. 2023.01–2025.12，叔膦PIII/PV=O催化杂环骨架的立体选择性构建与探索（湖南省教育厅重点项目），主持。
主要论文
27. Huamin Wang,* Li-Qin Meng, Wenjing Niu, Wan-Qi Yang, Yu Ou and Ying-Wu Lin*. The [3 + 2] Annulation of In Situ Formed Trifluorodiazoethane with 4-Nitroisoxazoles: Access to Trifluoromethylpyrazolo[3,4-d]isoxazoles. Chem. Commun. 2024, DOI: 10.1039/D4CC03826F.
26. Huamin Wang,* Yibo Wei, Yongjun He, Tian-Juan He, and Ying-Wu Lin*, Phosphine-Catalyzed Ring-Opening Regioselective Addition of Cyclopropenones with Amides. J. Or g. Chem. 2024, 89, 10093−10098.
25. Yongjun He#, Tian-Jun He#, Xiufang Cheng#, Yibo Wei, Huamin Wang*, Ying-Wu Lin*, Phosphine-catalyzed dearomative [3+2] cycloaddition of 4-nitroisoxazoles with allenoates or Morita–Baylis–Hillman carbonates. Chem. Commun. 2024, 60, 6961–6964. (#共一)
24. Shuang Tang, Li-Juan Sun, Ai-Qun Pan, Jun Huang, Huamin Wang*, Ying-Wu Lin*, Application of Engineered Myoglobins for Biosynthesis of Clofazimine by Integration with Chemical Synthesis. Org. Biomol. Chem. 2023, 21, 9603-9609.
23. Ze-Yuan Chen, Hong Yuan, Huamin Wang, Li-Juan Sun, Lu Yu, Shu-Qin Gao, Xiangshi Tan, Ying-Wu Lin*, Regulating the Heme Active Site by Covalent Modifications: Two Case Studies of Myoglobin. ChemBioChem 2023, e202300678.
22. Huamin Wang*, Wenjing Niu, Yongjun He, Yibo Wei, Xianxian Li, Ying-Wu Lin*. Synthesis of CF3‑Containing 2‑Imidazolines and Imidazoles via a Iodide-Promoted [3 + 2] Cyclization Reaction. J. Org. Chem. 2023, 88, 15282-15287.
21. Li-Juan Sun, Huamin Wang, Jia-Kun Xu, Shu-Qin Gao, Ge-Bo Wen, Ying-Wu Lin*, Exploiting and Engineering Neuroglobin for Catalyzing Carbene N−H Insertions and the Formation of Quinoxalinones. Inorg. Chem. 2023, 62, 16294–16298
20. Xiufang Cheng, Wenjin Niu, Huamin Wang*, Ying-Wu Lin*, β-Trifluoromethylated enones as trifluoromethylated synthons in asymmetric catalysis. Org. Chem. Front. 2023,10, 5519-5537
19. Xiufang Cheng,‡ Shuo Wang,‡ Yibo Wei,‡ Huamin Wang*，Ying-Wu Lin*. Metal-free hydrosulfonylation ofα,β-unsaturated ketones: synthesis and application of γ-keto sulfones. RSC Advances, 2022, 12, 35649-35654. (X.F.Cheng, S.Wang, Y.B.Wei共同第一作者)
18. Huamin Wang,* Yibo Wei, Yuqiang Li, Shuangshuang Long, Li-Juan Sun, Shixiong Li, and Ying-Wu Lin*. Phosphine-Catalyzed Atroposelective Formal [3 + 2] Cycloaddition Desymmetrization of N-Arylmaleimides. Org. Lett. 2022. 24, 6494-6498
17. Youshao Tu, Honglin Dong, Huamin Wang,* Yuhui Ao, Yu Liu*. Divergent functionalization of α,β-enones: catalyst-free access to β-azido ketones and β-amino α-diazo ketones. Chem. Commun. 2021, 57, 4524-4527.
16. Huamin Wang, Li Zhang, Youshao Tu, Ruiqi Xiang, Yin-Long Guo* and Junliang Zhang*. Phosphine-Catalyzed Difunctionalization of β-Fluoroalkyl α,β-Enones: A Direct Approach to β-Amino α-Diazo Carbonyl Compounds. Angew. Chem. Int. Ed. 2018, 57, 15787-15791.
15. Huamin Wang, Junyou Zhang, Youshao Tu and Junliang Zhang*. Phosphine-Catalyzed Enantioselective Dearomative [3+2]-Cycloaddition of 3-Nitroindoles and 2-Nitrobenzofurans. Angew. Chem. Int. Ed. 2019, 58, 5422-5426. (ESI高被引论文)
14. Huamin Wang, Xiuzheng Li, Youshao Tu and Junliang Zhang*. Catalytic Enantiodivergent Michael Addition by Subtle Adjustment of Achiral Amino Moiety of Dipeptide Phosphines. iscience 2020, 23, 101138-101148.
13. Huamin Wang, Weike Lu and Junliang Zhang*. Ferrocene Derived Bifunctional PhosphineCatalyzed Asymmetric Oxa-[4+2] Cycloaddition of a-Substituted Allenones with Enones. Chem. Eur. J. 2017, 23, 13587-13590.
12. Huamin Wang, Wei Zhou, Mengna Tao, Anjing Hu, Junliang Zhang*. Functionalized Tetrahydropyridines by Enantioselective Phosphine-Catalyzed Aza-[4+2] Cycloaddition of N Sulfonyl-1-aza-1,3-dienes with Vinyl Ketones. Org. Lett. 2017, 19, 1710-1713.
11. Huamin Wang, Jinhui Cai, Huawen Huang and Guo-Jun Deng*.Palladium-Catalyzed Phthalazinone Synthesis Using Paraformaldehyde as Carbon Source. Org. Lett. 2014, 16, 5324-5327.
10. Huamin Wang, Xiangxiang Cao, Fuhong Xiao, Saiwen Liu, Guo-Jun Deng*. IronCatalyzed One-Pot 2,3-Diarylquinazolinone Formation from 2 Nitrobenzamides and Alcohols. Org. Lett. 2013, 15, 4900-4903.
9. Huamin Wang, Hui Chen, Ya Chen, Guo-Jun Deng*. Palladium-catalyzed one pot 2-arylquinazoline formation via hydrogen-transfer strategy. Org. Biomol. Chem. 2014, 12, 7792-7799.
8. Wei Zhou, Huamin Wang, Mengna Tao, Chao-Ze Zhu, Tao-Yan Lin and Junliang Zhang*. Phosphine-catalyzed Enantioselective [3+2] Cycloadditions of γ-Substituted Allenoates with β-Perfluoroalkyl Enones. Chem. Sci. 2017, 8, 4660-4665.
7. Yongfeng Li, Huamin Wang, Yuwei Su, Runchen Li, Cao Li, Lu Liu,* and Junliang Zhang*. Phosphine-Catalyzed [3+2] Cycloaddition Reaction of α Diazoacetates and β Trifluoromethyl Enones: A Facile Access to Multisubstituted 4 (Trifluoromethyl)pyrazolines. Org. Lett. 2018, 20, 6444-6448.
6. Tiantian Cong, Huamin Wang, Xiuzheng Li, Hai-Hong Wu* and Junliang Zhang*. Chiral Bifunctional Bisphosphine Enabled Enantioselective Tandem Michael Addition of Tryptamine-Derived Oxindoles to Ynones. Chem. Commun. 2019, 55, 9176-9179.
5. Xiufang Cheng, Huamin Wang, Fuhong Xiao* and Guo-Jun Deng*. Lewis acid-catalyzed 2-arylquinazoline formation from N’-arylbenzimidamides and paraformaldehyde. Green Chem. 2016, 18, 5773-5776.
4. Tiantian Cong, Huamin Wang, Yuanyuan Liu, Hai-hong Wu and Junliang Zhang*. Phosphine-Mediated Sequential Staudinger/Aza-Michael Addition of Azides with Unsaturated Ketones to Synthesize beta-Amino Substituted Ketones. Chinese J Org Chem. 2019, 39, 2157-2165.
3. Jian-Jun Feng, Tao-Yan Lin, Chao-Ze Zhu, Huamin Wang, Hai-Hong Wu, and Junliang Zhang*. The Divergent Synthesis of Nitrogen Heterocycles by Rhodium(I)-Catalyzed Intermolecular Cycloadditions of Vinyl Aziridines and Alkynes. J. Am. Chem. Soc. 2016, 138, 2178-2181.
2. Jie Han, Wei Zhou, Pei-Chao Zhang, Huamin Wang, Ronghua Zhang, Hai-Hong Wu and Junliang Zhang*. Design and Synthesis of WJ-Phos, and Application in Cu-Catalyzed Enantioselective Boroacylation of 1, 1-Disubstituted Allenes. ACS Catalysis 2019, 9, 6890-6895.
1. Ben Huang, Cao Li, Huamin Wang, Caihui Wang, Lu Liu,* and Junliang Zhang*.Phosphine-Catalyzed Diastereo- and Enantioselective Michael Addition of β Carbonyl Esters to β Trifluoromethyl and β Ester Enones: Enhanced Reactivity by Inorganic Base. Org. Lett. 2017, 19, 5102-5105.
