基本信息
姓名：林英武
出生年月：1976.06
学位：博士
职称：教授
研究领域（方向）：金属蛋白/金属酶结构与功能
联系方式：
邮箱：ywlin(a)usc.edu.cn; linlinying(a)hotmail.com
个人简介
林英武，男，安徽安庆人，南华大学教授，博士生导师。日本JSPS学者、湖南省杰出青年基金获得者、湖南省121创新人才，湖南省首届“优秀研究生导师”。现任化学化工学院院长，蛋白质结构与功能湖南省高校重点实验室主任。相关科研成果发表于Nature、PNAS、JACS、Angew Chem、Coord Chem Rev、ACS Catalysis、Chem Commun、中国科学（化学）等国内外期刊累计200余篇，其中第一作者或通讯作者SCI论文100余篇。2017年1月-2020年12月，任国际学术期刊ChemistryOpen 期刊编委。2019年获得衡阳市“青年英才”奖；2020年获得“徐元植顺磁共振波谱学优秀青年奖”； 2022年获得衡阳市首届“优秀科技工作者”称号。2022年8月，入选中国化学会第四届生物物理化学专业委员会委员。2022年和2023年连续入选斯坦福大学全球前2%顶尖科学家榜单。
教育经历
2002/09-2005/12，复旦大学化学系，博士，导师：黄仲贤
1999/09-2002/06，中科院上海原子核研究所，硕士，导师：尹端沚
1995/09-1999/06，安徽师范大学，化学系，本科/学士
科研、学术与访学工作经历
2008/07-2010/06美国伊利诺伊大学香槟分校（University of Illinois at Urbana-Champaign, UIUC）化学系从事博士后研究（导师：Prof. Yi Lu）
2013/05-2013/11日本奈良先端科学技术大学（Nara Institute of Science and Technology, NAIST）从事科研合作研究（JSPS访问学者，合作者Prof. Shun Hirota）
主持或参加科研项目（课题）情况
主持国家自然基金面上项目（3项）、国家自然基金青年项目（1项）、教育部留学回国启动基金、湖南省自然科学杰出青年基金、南京大学配位化学国家重点实验室开放基金等。
主要论文
2009-2022
1. Natasha Yeung,Ying-Wu Lin, Yi-Gui Gao, Xuan Zhao, Brandy S. Russell, Lanyu Lei, Kyle D. Miner, Howard Robinson, and Yi Lu*. Rational design of a structural and functional nitric oxide reductase. Nature, 2009, 462(7276): 1097-1082.
2. Ying-Wu Lin, Natasha Yeung, Yi-Gui Gao, Kyle D. Miner, Shiliang Tian, Howard Robinson, and Yi Lu*. Roles of glutamates and metal ions in a rationally designed nitric oxide reductase based on myoglobin.Proc Natl Acad Sci USA, 2010, 107(19): 8581-8586.
3. Ying-Wu Lin, Natasha Yeung, Yi-Gui Gao, Kyle D. Miner, Lanyu Lei, Howard Robinson, and Yi Lu*. Introducing a non-heme iron center into myoglobin confers nitric oxide reductase activity. J Am Chem Soc, 2010, 132(29): 9970-9972.
4. Ying-Wu Lin, Satoshi Nagao, Mohan Zhang, Yasuhito Shomura, Yoshiki Higuchi, Shun Hirota*. Rational Design of Heterodimeric Protein Using Domain Swapping for Myoglobin. Angew. Chem. Int. Ed. 2015, 54(2):511-5.
5. Ying-Wu Lin*. Rational design of metalloenzymes: From single to multiple active sites. Coord Chem Rev 2017, 336:1-27.(Review)（IF=15.367 ESI高被引论文; Cited by Nature Reviews Chemistry, Trends in Biochemical Sciences, Current Opinion in Chemical Biology, etc)
6. Ying-Wu Lin*. Biodegradation of aromatic pollutants by metalloenzymes: A strcutural-functional-environmental perspective. Coord Chem Rev 2021,（IF=22.315)
7. Xiaojuan Wang, Chuanwan Wei*, Ji-Hu Su, Bo He, Ge-Bo Wen, Ying-Wu Lin* and Yi Zhang*. A Chiral Ligand Assembly that Confers One-electron O2 Reduction Activity for a Cu2+-selective Metallohydrogel. Angew Chem Int Ed, 2018,doi: 10.1002/anie.201801290.(IF=12.959）
8. Xiao-Feng Wang*, Yangyang Chen, Li-Ping Song, Zhen Fang, Jian Zhang, Fanian Shi, Ying-Wu Lin*, Yunkai Sun, Yue-Biao Zhang*, João Rocha*.Cooperative Capture of Uranyl Ions by a Carbonyl-Bearing Hierarchical-Porous Cu-Organic Framework. Angew Chem Int Ed, 2019,58(52):18808-18812.（IF=12.959）（Hot Paper）
9.Lu-Lu Yin, Hong Yuan, Can Liu, Bo He, Shu-Qin Gao, Ge-Bo Wen, Xiangshi Tan and Ying-Wu Lin*. A Rationally Designed Myoglobin Exhibits a Catalytic dehalogenation Efficiency More than 1000-Fold that of a Native Dehaloperoxidase. ACS Catalysis, 2018, DOI: 10.1021/acscatal.8b02979. ( IF=12.35）
10. Ping Zhang, Jiakun Xu,Xiao-Juan Wang, Bo He, Shu-Qin Gao, Ying-Wu Lin*. The Third Generation of Artificial Dye-Decolorizing Peroxidase Rationally Designed in Myoglobin, ACS Catalysis, 2019, DOI: 10.1021/acscatal. 9b02226. (IF=12.35）
11. Ping Zhang, Hong Yuan, Jiakun Xu,Xiao-Juan Wang, Shu-Qin Gao, Xianshi Tan, Ying-Wu Lin*. A Catalytic Binding Site together with a Distal Tyr in Myoglobin Affords Catalytic Efficiencies Similar to Natural Peroxidases, ACS Catalysis, 2020,10, 1, 891-896 (IF=12.35）
12. Jie Luo, Ke-Jie Du, Hong Yuan, Chuan-Wan Wei, Jia-Jia Lang, Ge-Bo Wen, Yong-Hua Wang, and Ying-Wu Lin*. Rational Design of an Artificial Nuclease by Engineering a Hetero-Dinuclear Center of Mg-Heme in Myoglobin. ACS Catalysis, 2020,10, 24, 14359–14365 (IF=12.35）
13. Lu-Lu Yin, Hong Yuan, Ke-Jie Du, Bo He, Shu-Qin Gao, Ge-Bo Wen, Xiangshi Tan and Ying-Wu Lin*. Regulation of both structure and function by a de novo designed disulfide bond: A case study of heme protein in myoglobin. Chem Commun, 2018, DOI: 10.1039/C8CC01646A.(IF=6.164）
14. Can Liu, Hong Yuan, Fei Liao, Chuan-Wan Wei, Ke-Jie Du, Shu-Qin Gao,Xiangshi Tan and Ying-Wu Lin*.Unique Tyr-heme double cross-links in F43Y/T67R myoglobin: an artificial enzyme with a peroxidase activity comparable to that of native peroxidases. Chem Commun, 2019, DOI: 10.1039/C9CC02714A (IF=6.164）
15. Li-Juan Sun, Hong Yuan, Lu Yu, Shu-Qin Gao, Ge-Bo Wen, Xiangshi Tan and Ying-Wu Lin*. Structural and functional regulations by a disulfide bond designed in myoglobin like human neuroglobin. Chem Commun, 2022, 58, 5885-5888. (IF=6.164）
16. Lei Chen, Hong Yuan, Xiao-Juan Wang, Lianzhi Li, Xianshi Tan, Ying-Wu Lin*. Engineering Human Neuroglobin into a Cytochrome c-like Protein with a Single Thioether Bond in Non-native State. ChemBioChem, 2022, https://doi.org/10.1002/cbic.202200531
2023
17. Lang JJ, Lv Y, Kobe B, Chen H, Tan Y, Chen L, Wang X, Mi P,* Zheng X,* Lin YW.* Discovery of C-5 Pyrazole-Substituted Pyrrolopyridine Derivatives as Potent and Selective Inhibitors for Janus Kinase 1. J Med Chem, 2023, 66:6725-6742. DOI:10.1021/acs.jmedchem.3c00050 (IF=7.3）
18. Li-Juan Sun,Hong Yuan,Jia-Kun Xu,Jie Luo,Jia-Jia Lang,Ge-Bo Wen,Xiangshi Tan, Ying-Wu Lin*. Phenoxazinone Synthase-like Activity of Rationally Designed Heme Enzymes Based on Myoglobin. Biochemistry 2023, https://pubs.acs.org/doi/10.1021/acs.biochem.1c00554
19. Yu Feng, Yao Dong, Ke-Jie Du*, Xi-Chun Liu, Shu-Qin Gao, Ying-Wu Lin*. The oxidative nuclease activity of human cytochrome c with mutations in Ω-loop C/D. BBA,Proteins and Proteomics. 2023, https://doi.org/10.1016/j.bbapap.2023.140897
20. Wei Dai, Hong Yuan, Xiao-Juan Wang; Shu-Qin Gao, Xiangshi Tan; Ying-Wu Lin.* Self-oxidation of cysteine to sulfinic acid in an engineered T67C myoglobin: Structure and reactivity. RSC Chem Biol, 2023, https://doi.org/10.1039/D3CB00007A
21. Binbin Yuan, Shuangshuang Long*, Huamin Wang; Qing Liu, Ke Zeng, Shuqing Gao, Yingwu Lin.* Surfactant-regulated acetylpyrene assemblies as fluorescent probes for identifying heme proteins in an aqueous solution. CCL, 2023, , https://doi.org/10.1016/j.cclet.2022.107802, (IF=8.455）
22. Li Yan-Yan, Long Shuang-Shuang,* Yu Lu, Liu AK, Gao Sh-Qin, Tan Xiangshi, Lin Ying-Wu*. Effects of naturally occurring S47F/A mutations on the structure and function of human cytochrome c. J Inorg Biochem, 2023, DOI: 10.1016/j.jinorgbio.2023.112296.
23. Chen YM, Liu YC, Wang JQ, Ou GC, Wang XF, Gao SQ, Du KJ,* Lin YW.* Functional copper complexes with benzofurans tridentate ligand: Synthesis, crystal structure, DNA binding and anticancer studies. J Inorg Biochem, 2023, DOI:10.1016/j.jinorgbio.2023.112330
24. Yu QY, Wei CW, Wang XJ*, Gao SQ, Tong XY, Lin YW.* A fluorescent probe based on a phenylalanine derivative is capable of sequential detection of Zn2+ and Cys/His. J Biol Inorg Chem, 2023, 8(2):205-211. DOI:10.1007/s00775-022-01984-x
25. Xin Zhang, Ling-Hua Jin, Yan-Yan Li, Zi-Zhen Xiao, Yu Feng, Ying-Wu Lin*, and Ye Zhang.* Portable self-powered photoelectrochemical immunosensor based on Cu3SnS4 nanoflower for ultra-sensitive and real-time detection of human cytochrome c. Inorg Chem Front, 2023, https://pubs.rsc.org/en/content/articlelanding/2023/qi/d3qi01234d (IF=7.0)
26.Sun LJ, Wang H, Xu JK, Gao SQ, Wen GB, Lin YW.* Exploiting and Engineering Neuroglobin for Catalyzing Carbene N-H Insertions and the Formation of Quinoxalinones. Inorg Chem, 2023, DOI: 10.1021/acs.inorgchem.3c02855
27.Chunhui Wang, Keyi Xian, Shuangshuang Zhao, Shuailing Ma, Haozhe Qin, Dong Wang, Akhil Tayal, Yanfei Wang, Ying-Wu Lin*, Ming Feng*, Xing Ou*. The synergy of ferric surface anchoring and interior doping engineering enables anode with boosted potassium ion storage performances. Nano Energy, 2023, 118(A): 109020. https://www.sciencedirect.com/science/article/abs/pii/S2211285523008571 (IF=17.6)
28. Guang-Rong Wu, Jia-Kun Xu*, Li-Juan Sun, Ying-Fu Li, Shu-Qin Gao, Ying-Wu Lin*. Application of engineered heme enzymes based on myoglobin with high peroxidase activity for efficient degradation of various emerging pollutants. J Environ Chem Eng, 2023,11(6): 111471 (IF=7.7) https://www.sciencedirect.com/science/article/abs/pii/S2213343723022108
29. Shuai Tang, Li-Juan Sun, Ai-Qun Pan,, Jun Huang, Huamin Wang*, Ying-Wu Lin*. Application of Engineered Myoglobins for Biosynthesis of Clofazimine by Integration with Chemical Synthesis. Org Biomol Chem, 2023, 21(48):9603-9609. https://pubs.rsc.org/en/content/articlelanding/2023/ob/d3ob01687k/unauth
2024-
30. Ying-Wu Lin*. Functional metalloenzymes based on myoglobin and neuroglobin that exploit covalent interactions. J Inorg Biochem, 2024, DOI:https://doi.org/10.1016/j.jinorgbio.2024.112595 (Invited by Editor Prof. J.H. Dawson)
31. Wu ST,* Su HQ, Xiao QX, Qiu ZY, Huang GQ, He MN, Ge Y, Wang CH, Lin YW.* Design of bifunctional ultrathin MnO2 nanofilm with laccase-like activity for sensing environmental pollutants containing phenol groups. J Hazard Mater. 2024,461:132493.DOI: 10.1016/j.jhazmat.2023.132493 (IF=13.6)
32. Sheng-Tao Wu,* Hui-Qi Su, Kai-Lin Shen, Ying Li, Yi Ge, Xiu-Fang Cheng, Chang-Ming Nie, Cong-Hui Wang, Ying-Wu Lin*. Tuning multiple enzyme-like activities by metal doping for identification and quantitation of antioxidants in cosmetics. Chem Eng J, 2024, DOI: https://doi.org/10.1016/j.cej.2024.152120 (IF=15.1)
33. Pengbing Mi,* Yan Tan, Shiying Ye , Jia-Jia Lang, You Lv, Jinhuan Jiang, Limei Chen, Jianxiong luo, Yuqing Lin, Zhonghua Yuan*, Xing Zheng*, Ying-Wu Lin*. Discovery of C-3 isoxazole substituted thiochromone S,S-dioxide derivatives as potent and selective inhibitors for monoamine oxidase B (MAO-B). Eur J Med Chem, 2024,263: 115956 (IF=6.7) https://www.sciencedirect.com/science/article/abs/pii/S0223523423009236
34. Chen L, Tang Y, Lang JJ, Lin Y, Yu Z, Li X, Zheng X, Mi P*, Lv Y*, Lin YW.* Design, synthesis and evaluation of C-5 substituted pyrrolopyridine derivatives as potent Janus Kinase 1 inhibitors with excellent selectivity. Eur J Med Chem, 2024,267:116210. (IF=6.7) DOI: 10.1016/j.ejmech.2024.116210
35. Ze-Yuan Chen, Hong Yuan, Huamin Wang, Li-Juan Sun, Lu Yu, Shu-Qin Gao, Xiangshi Tan, Ying-Wu Lin*. Regulating the Heme Active Site by Covalent Modifications: Two Case Studies of Myoglobin. ChemBioChem, 2024, DOI: https://doi.org/10.1002/cbic.202300678
36. Yan-Yan Li, Yu Feng, Lu Yu, Shuang-Shuang Long*, Shu-Qin Gao and Ying-Wu Lin*. Design and engineering of an artificial disulfide bond in human cytochrome c to regulate the protein structure and function. Mol. Syst. Des. Eng., 2024, DOI: https://doi.org/10.1039/D3ME00196B
专利
